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Report - - AstraZeneca/Avara/Avlon Works Pharma Facility (Part 3) - Avonmouth, April 2021 | Industrial Sites | 28DaysLater.co.uk

Report - AstraZeneca/Avara/Avlon Works Pharma Facility (Part 3) - Avonmouth, April 2021

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Imba

28DL Full Member
28DL Full Member

907294



Good evening everyone, continuing from where I left off from part 2...

Again, if you'd like to learn a bit more of the history, that can be found back in part 1 :thumb

This part will cover the R&D labs on the site, plus another of the API plants.... It was around this time that I had spotted security wandering around, so the quality of the pictures does start to go a little over the place.

If you're not too interested in the labs and would like to see more of that sweet heavy industrial machinery and pipe porn, there is a large dose of that starting on the second post.


EXPLORE

To help get a bit of a clearer idea of where I've been to on this site in previous parts, and where I'm going in this post, I've annotated a picture with my amazing MS paint skills:

1 - Wastewater treatment plant (Part 1)
2 - Combined heat and power plant (Part 1)
3 - The 5-floor ingredient plant (Part 2)
4 - R&D labs/catalyst screening facility (Part 3)

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So, this was where I bumped into my lovely AZ incident controller friend. Walking into the opposite end of the room to him, with his back to me, it was quite the shock... for all of 2 seconds. It looked like whoever had done this used some of the chemical spill kits that have long sausage-shaped sandbags to stuff him.

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It looked like the room he was in was mainly used for fire safety and control.

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It was extremely tempting to try one of these on...

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Moving on from here, I ended up in a super long hallway, with locker rooms, offices, meeting rooms, and finally, some labs down the end.

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There appeared to be at least 6 labs that looked like this, all of them varying in the amount of stripping that had taken place. Some still had machinery, boxes of equipment left on shelves, etc.

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These labs were all part of the catalyst screening facility. Catalyst screening is an important part of process route scouting in pharmaceutical drug substance development.

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Process research, also known as route scouting, is to design and demonstrate new synthetic routes or methodologies with a focus on IP, safety, costs, atom efficiency, quality and delivery to meet the goal of sustainability in the pharmaceutical industry.

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Comprehensive catalyst screening provides breakthroughs in problematic synthetic conversions and leads to processes that are more efficient.

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Chemistry that involves catalysts is highly specialized: catalysts are often air sensitive; reactions may be carried out under pressure, and are often conducted initially at small (µM) scale.

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Furthermore, synthetic target molecules in R&D are becoming more complex requiring complex synthetic routes. As a result, many organizations are investing in specialized catalysis groups to support screening activities.

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Many organizations have invested in elaborate lab automation equipment and robotics to speed process development efforts. However, the variety of systems required to support screening workflows require repeated, often-tedious transcription from one software interface to another; this increases the risk of errors and incorrect experiment conclusions.

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Starting to make my way up to the first floor now.

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The labs through these doors appeared to have been the largest in the building. Unfortunately, only a couple of fume cupboards at one end were all that remained.

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There were stairs up from the first floor, but apart from roof access, there were just a couple of small electrical control rooms.

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Continued in the post below - things are just about to get even juicier...


 

Imba

28DL Full Member
28DL Full Member
Right, we are all done with the R&D labs. Time to make our way over to one of the API (active pharmaceutical ingredient) plants... Just a few more shots of the site going through demolition as we move between the buildings.

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The first part of this API plant I entered through seemed to be the main reception/control room.

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Here we go - the API produced in this plant was hydrogen fumarate.

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So this plant, along with a majority of the rest, appeared to be more modern than the large 5-floor one I explored in the previous part. The condition of this building was impeccable.

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So, I believe that the form of hydrogen fumarate that was produced here is more commonly known as tiamulin fumarate... I hesitate to say for sure though, as my research turned up a few different compounds, but tiamulin appeared to be the most commonly known/used... so that's what I'll be dropping a little more info about.

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Tiamulin is an antibiotic belonging to the class of pleuromutilins. It works by preventing certain bacteria from making proteins, thereby stopping their growth. Tiamulin has been shown to work against some microorganisms which infect pigs, chickens and rabbits.

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Tiamulin is only used in veterinary medicine and is usually given to animals in their food or water. In pigs, it is often used to treat a bacterial infection called swine dysentery, but it can also be used for the prevention or metaphylaxis of that infection. This means not for treating pigs that are already diseased, but to protect healthy animals when they are at risk of becoming infected.

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The Belgian veterinary medicines authority noted new data which showed that Brachyspira hyodysenteriae, the bacterium which causes swine dysentery, is increasingly developing resistance against tiamulin, which will reduce its effectiveness.

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Antibiotic resistance is the ability of bacteria to grow in the presence of an antibiotic that would normally kill them or limit their growth. This means that the antibiotic may no longer work on bacteria infecting either animals or humans.

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When using tiamulin only for the prevention or metaphylaxis of swine dysentery (not at the same time as treating diseased pigs), usually very low doses for a prolonged period of time (mostly 4-6 weeks) were approved, to cover the period for which the animals were considered at risk. It is generally accepted that using such small amounts of antibiotics for a long duration contributes to the development of antibiotic resistance.

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I think this next shot was one of my favourites of the day.

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Okay, looks like that is the end of this part. We'll leave it with another picture of some stairs.

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Thank you everyone, once again, if you have made it this far :thumb These first 3 parts cover my first half day on this site, and I still have 2 more days to cover... Stay tuned for the next part!

But just before I go, a little teaser of what is coming next, this place just kept on giving...

(The rooms in this milling plant were in complete darkness, so I had to illuminate the shots as best I could with my torch)

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Mikeymutt🐶

28DL Regular User
Regular User
You are certainly right. This place keeps on giving and giving. Great work, look forward to the next parts.
 

Seffy

Moderator
Staff member
Moderator
Part three! Absolute blinder that. All neatly organised and easy to read too; you’ve treated us well here mate :thumb
 

Calamity Jane

i see beauty in the unloved, places & things
Regular User
Excellent stuff. Part 3 is cracking. Images so clear and have a wow factor. Loving your series. :cool:
 

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